Article
APOBEC-mediated DNA alterations: a possible new mechanism of carcinogenesis in EBV-positive gastric cancer
2018-11-19
Abstract excerpt
Mechanisms of viral oncogenesis are diverse and include the off-target activity of enzymes expressed by the infected cells, which evolved to target viral genomes for controlling their infection. Among these enzymes, the single-strand DNA editing capability of APOBECs represent a well-conserved viral infection response that can also cause untoward mutations in host DNA. Here we show, after evaluating somatic single...
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Identifiers and source
- Literature Corpus work
- e926a25d-9d95-5617-a073-73aca5ca2e23
- DOI
- 10.1101/473884