Article

Denoising of Fluorescence Lifetime Imaging Data via Principal Component Analysis

2025-07-29

Abstract excerpt

<title>Abstract</title> <p>Fluorescence Lifetime Imaging Microscopy (FLIM) quantifies autofluorescence lifetime to assess cellular metabolism, therapeutic efficacy, and disease progression. These dynamic and heterogeneous processes complicate signal analysis. Fit-free analysis methods such as phasor analysis are increasingly used due to limitations of fit-based approaches. However, incorporating photon-counting s...

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Literature Corpus work: e912d6fb-5af5-5d1b-9e45-b9358a8ad9a1
DOI: 10.21203/rs.3.rs-7143126/v1

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