Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models

Abstract excerpt

Metabolic preferences of tumor cells vary within a single tumor, contributing to tumor heterogeneity, drug resistance, and patient relapse. However, the relationship between tumor treatment response and metabolically distinct tumor cell populations is not well understood. Here, a quantitative approach was developed to characterize spatial patterns of metabolic heterogeneity in tumor cell populations within in...

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