Article

The Case Against Censoring of Progression-Free Survival in Cancer Clinical Trials – A Pandemic Shutdown as an Illustration

2021-12-30

Abstract excerpt

Missing data may lead to loss of statistical power and introduce bias in clinical trials. The ongoing Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials. Restricted access to sites, medication and evaluations brings challenges to the analysis of clinical trials due to missing data. Although several endpoints may be affected, progression-free survival (PF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8d63a22-fffa-51ef-adc6-04b68e9c2393
DOI: 10.21203/rs.3.rs-1033601/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Case Against Censoring of Progression-Free Survival in Cancer Clinical Trials – A Pandemic Shutdown as an IllustrationDOI 10.21203/rs.3.rs-1033601/v1Read

Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non-Small Cell Lung or Colorectal Cancer.Semantic proximity Read

Empirical methods for the validation of Time-To-Event mathematical models taking into account uncertainty and variability: Application to EGFR+ Lung AdenocarcinomaSemantic proximity Read

Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportionalSemantic proximity Read

Patient-Reported Symptom Assessments and Early Chemotherapy Discontinuation in Routine Gastrointestinal Cancer CareSemantic proximity Read

Leveraging Longitudinal Patient-Reported Outcomes Trajectories to Predict Survival in Non-Small-Cell Lung CancerSemantic proximity Read

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancerSemantic proximity Read

Impact of Clinical Trial Participation on Survival of Patients with Metastatic Non-Small Cell Lung Cancer.Semantic proximity Read

Single-arm Trials with Historical ControlsSemantic proximity Read

Quantifying bias from dependent left truncation in survival analyses of real world dataSemantic proximity Read

Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortalitySemantic proximity Read

When Does IPCW Help? Simulation and Real-World Evidence on Censoring Adjustment in Survival AnalysisSemantic proximity Read

Curtailed phase II binary outcome trials and adaptive multi-outcome trialsSemantic proximity Read