Article

Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

2025-08-19

Abstract excerpt

Meta-analysis is a vital component in clinical decision making, but previous work found binary event meta-analytic results can be fragile, affected by only a small number of patients in specific trials. Meta-analyses can also miss literature, and a method for estimating how much additional unseen data would flip results would be a useful tool. This works establishes a complementary and generalisable definition of...

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Literature Corpus work: 1ac69b77-95c1-50d4-9694-5d520607e958
DOI: 10.1101/2025.08.15.25333793

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