Article

MicroRNA combinations function as synergistic network regulators of neuroblastoma differentiation

2026-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Differentiation-based therapies represent a promising strategy for the treatment of neuroblastoma; however, single-agent approaches frequently yield incomplete and transient responses due to the robustness of underlying gene regulatory networks. MicroRNAs (miRNAs) are endogenous regulators of gene expression that modulate entire gene programs rather than individual molecular targets, making them...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8b8bf1f-1264-5b7f-8a81-83c3b9bbfb74
DOI: 10.64898/2026.03.04.709166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA combinations function as synergistic network regulators of neuroblastoma differentiationDOI 10.64898/2026.03.04.709166Read

A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiationSemantic proximity Read

Differential Patterns of MicroRNA Expression in Neuroblastoma Are Correlated with Prognosis, Differentiation, and ApoptosisSemantic proximity Read

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAsSemantic proximity Read

Discovering cancer vulnerabilities using high-throughput micro-RNA screening.Semantic proximity Read

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastomaSemantic proximity Read

Drug and disease signature integration identifies synergistic combinations in glioblastomaSemantic proximity Read

Defining principles of combination drug mechanisms of action.Semantic proximity Read

Identifying miRNA synergism using multiple-intervention causal inferenceSemantic proximity Read

A statistical framework for defining synergistic anticancer drug interactionsSemantic proximity Read

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastomaSemantic proximity Read

Diverse array-designed modes of combination therapies in Fangjiomics.Semantic proximity Read

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergismsSemantic proximity Read