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Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparum

2022-07-25

Abstract excerpt

<h4>Background: </h4> The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly targeted in diagnostics for Plasmodium falciparum ( Pf ) detection. The frequency of such deletions can be determined in publically available Pf whole genome se...

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Literature Corpus work
e87d544a-b09c-5f2e-a507-432b5b4b7026
DOI
10.21203/rs.3.rs-1862557/v1
Open publication

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Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparumDOI 10.21203/rs.3.rs-1862557/v1
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