Article

Egyptian rousette bat macrophages elicit divergent interferon responses and cytokine storm signalling against Marburg and Sudan viruses

2025-08-07

Abstract excerpt

Egyptian rousette bats (ERBs) are the only known natural reservoir of Marburg virus (MARV), etiologic agent of a highly-pathogenic zoonotic viral hemorrhagic fever. In ERBs, evolutionary adaptations allow for fine-tuned discrete pro-inflammatory immune responses that control MARV infection, yet permit population-level viral maintenance. To look for exclusive co-adapted responses between ERBs and MARV, we compared...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e838d936-7ebf-5e2f-91e7-119c1f9646b3
DOI: 10.1101/2025.08.05.668667

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Egyptian rousette bat macrophages elicit divergent interferon responses and cytokine storm signalling against Marburg and Sudan virusesDOI 10.1101/2025.08.05.668667Read

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific CellsSemantic proximity Read

Transcriptomics Reveal Antiviral Gene Induction in the Egyptian Rousette Bat Is Antagonized In Vitro by Marburg Virus InfectionSemantic proximity Read

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in batsSemantic proximity Read

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.Semantic proximity Read

Landscape and age dynamics of immune cells in the Egyptian rousette batSemantic proximity Read

Comparison of antiviral responses in two bat species reveals conserved and divergent innate immune pathwaysSemantic proximity Read

Reconstructing bat antiviral immunity using epithelial organoidsSemantic proximity Read

Single-cell transcriptional atlas of the Chinese horseshoe bat ( <i>Rhinolophus sinicus</i> ) provides insight into the cellular mechanisms which enable bats to be viral reservoirsSemantic proximity Read

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter systemSemantic proximity Read

A comparative analysis of Marburg virus-infected bat and human models from public high-throughput sequencing dataSemantic proximity Read

The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL InductionSemantic proximity Read

Genomic features of humoral immunity support tolerance model in Egyptian rousette batsSemantic proximity Read