A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration

Abstract excerpt

Epithelial cells in the skin and other tissues rely on signals from their environment to maintain homeostasis and respond to injury, and G protein-coupled receptors (GPCRs) play a critical role in this communication. A better understanding of the GPCRs expressed in epithelial cells will contribute to understanding the relationship between cells and their niche and could lead to developing new therapies to modulate...

Topics

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• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Genotype
• Gut microbiota and health
• Ligands
• Phenotype
• Pseudogenes
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

e8364e5a-11a2-5597-92a6-5a4dd97e80a4

DOI

10.1101/2023.05.30.542853