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Somatic reversion impacts MDS/AML evolution in the short telomere syndromes

2021-05-27

Abstract excerpt

Inherited mutations in telomerase and other telomere maintenance genes manifest in the premature aging short telomere syndromes. Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers overcome the germline telomere defect is unknown. We used targeted ultra-deep sequencing to detect candidate somatic reversion mutations hypothesizing they may...

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Identifiers and source

Literature Corpus work
e8304967-5c5d-5fe9-84ed-273a5150aca3
DOI
10.1101/2021.05.26.445858
Open publication

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Somatic reversion impacts MDS/AML evolution in the short telomere syndromesDOI 10.1101/2021.05.26.445858
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