Article

Mucin-enriched environment shapes bacteriophage protection against <i>Pseudomonas aeruginosa</i> in airway epithelial cells

2025-10-17

Abstract excerpt

Mucin hypersecretion, a hallmark of chronic respiratory diseases (CRD), creates a complex microenvironment that reshapes host immunity and microbial behavior. However, its impact on bacteriophage therapy remains poorly understood. Here, we demonstrate that, despite reducing Pseudomonas aeruginosa internalization, exogenous mucin increases bacterial-induced cytotoxicity and inflammation in airway epithelial cells,...

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Literature Corpus work: e7fb276a-f37b-5c23-a9b7-4d05f6651f6b
DOI: 10.1101/2025.10.17.683030

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