Article

Methylmalonic acid: a new target for Hadamard-edited MRS

2026-06-09

Abstract excerpt

<h4>Background</h4> Methylmalonic acidemia (MMAemia) is a genetic metabolic disorder characterized by an accumulation of methylmalonic acid (MMA) and impaired energy metabolism leading to increased lactate (Lac). The signals of MMA (1.23 ppm) and Lac (1.33 ppm) overlap, making their separation using conventional MRS challenging. An MRS method to differentiate the two metabolites could enhance pathophysiological u...

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Literature Corpus work: e7d991b2-c27c-599c-adb3-09f4eb7fe2a7
DOI: 10.64898/2026.06.05.730405

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