GABA editing with macromolecule suppression using an improved MEGA‐SPECIAL sequence

Abstract excerpt

Purpose The most common γ‐aminobutyric‐acid (GABA) editing approach, MEGA‐PRESS, uses J‐editing to measure GABA distinct from larger overlapping metabolites, but suffers contamination from coedited macromolecules (MMs) comprising 40 to 60% of the observed signal. MEGA‐SPECIAL is an alternative method with better MM suppression, but is not widely used primarily because of its relatively poor spatial localization....

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