Article
In vivo assignment of methylmalonic acid in breast tissue using 2D MRS and relationship with breast density, menopausal status and cancer risk.
NMR in biomedicine - 1 Mar 2023
Santamaría Gorane, Naude Natali, Bennett Ian, Vosburgh Kirby, Ganau Sergi, Bargalló Xavier, Malycha Peter, Mountford Carolyn
Abstract excerpt
BACKGROUND: Methylmalonic acid (MMA) is linked to progression and aggressiveness of tumours. A recent study showed that high levels of circulatory MMA directed genetic programs promoting cancer progression. PURPOSE: To evaluate in vivo two-dimensional correlated spectroscopy (2D COSY) data from women at elevated risk of breast cancer to determine if resonances consistent with MMA are present, and if so to...
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