Article

Matrix remodeling plays an etiological role in driving laminin-α2 deficient pathology

2026-07-02

Abstract excerpt

Laminin-α2 (gene: LAMA2 ) is a key protein in the basement membrane of muscle and Schwann cells. A complete lack of this protein results in LAMA2-related congenital muscular dystrophy (LAMA2-RD), a severe muscle disease characterized by progressive muscle weakness, respiratory insufficiency, failure to thrive and shortened life span. One key signature of this disease is early onset of fibrosis coupled with poor m...

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Literature Corpus work: e788eac8-eef9-5f53-ab12-382f31d5714e
DOI: 10.64898/2026.06.28.735063

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