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Article

Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype.

The Journal of clinical investigation - 1 Mar 2017

McKee Karen K, Crosson Stephanie C, Meinen Sarina, Reinhard Judith R, Rüegg Markus A, Yurchenco Peter D

Abstract excerpt

Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately 30% of congenital muscular dystrophy cases. Mice with a homozygous mutation in Lama2 (dy2J mice) express a nonpolymerizing form of laminin-211 (Lm211) and are a model for ambulatory-type Lmα2-deficient muscular dystrophy. Here, we developed transgenic dy2J mice with muscle-specific expression of αLNNd, a laminin/nidogen chimeric...

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Share to LAMA2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laminin

Share to Mice, Transgenic

Share to Muscular Dystrophy, Animal

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Source

Open in PubMed Open full text

Identifiers

PMID: 28218617
DOI: 10.1172/JCI90854
PMCID: PMC5330723

Genes

LAMA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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