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Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation

12 Jan 2024

Abstract excerpt

Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations associated with conventional manufacturing methods. iPSCs offer an off-the-shelf source of therapeutic T cells with the potential for infinite expansion and straightforward genetic manipulation to ensure hypo-immunogenicity and...

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PMID: 38283344
DOI: 10.3389/fimmu.2023.1325209

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