Article

Functional gradient perturbation in Wilson disease correlates with structural lesions and transcriptomic specializations

2023-06-20

Abstract excerpt

Functional dysregulations in multiple regions are caused by excessive copper deposition in the brain for Wilson disease (WD). While the biological mechanism of these dysregulations was thought to be the absent or reduced expression of the ATP7B protein in the liver, mechanisms for such gene impacting brain function remain unexplored. Here, we used a large cohort of resting-state fMRI data (105 WD patients and 93 h...

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Literature Corpus work: e74639bc-28b3-5dcd-baf6-02421f698eab
DOI: 10.1101/2023.06.19.23291569

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