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BRAFV600E Mutation Drives Cisplatin Resistance in Colorectal Cancer by Attenuating Ferroptosis Through the NF-κB/Lipocalin 2 Signaling Pathway

2026-06-26

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose:</bold> Colorectal cancers (CRCs) harboring the BRAFV600E (V600E) mutation exhibit aggressive behavior and chemotherapy resistance, yet the underlying mechanisms remain poorly understood. Ferroptosis, which is driven by iron-dependent lipid peroxidation, has emerged as a promising process. This study aimed to determine whether BRAFV600E regulates cisplatin sensitivity b...

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Literature Corpus work: e73ed13b-3e0b-5ce4-bd11-5b8d2f28c120
DOI: 10.21203/rs.3.rs-10147889/v1

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