Article

Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene

2025-09-02

Abstract excerpt

<h4>Introduction</h4> A prior integrative, multi-omics human genetics and functional genomics study identified maelstrom ( MAEL ), a gene involved in regulation of DNA transposon activity and genome structure, as a transcriptome-wide predictor of hydrocephalus (HC) in the brain cortex. Here we expand on this discovery and further characterize the evolutionary origin and expression of MAEL across developmental tim...

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Literature Corpus work: e6ea6a66-8698-5230-8f9e-bb21d03ed45d
DOI: 10.1101/2025.09.01.25334358

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