Article

Molecular Determinants for Differential Activation of the <i>Vibrio parahaemolyticus</i> Bile Acid Receptor

2022-09-02

Abstract excerpt

Bile acids are important for digestion of food and for antimicrobial activity. Pathogenic Vibrio parahaemolyticus senses bile acids via the co-component signal transduction system receptor VtrA/VtrC, an obligate membrane heterodimer. Intestinal bile acids bind to the periplasmic domain of the VtrA/VtrC complex, activating a DNA-binding domain in VtrA that induces expression of another membrane protein, VtrB. VtrB...

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Literature Corpus work: e67d986a-3bc0-54f8-a9c7-1bd55113957e
DOI: 10.1101/2022.09.02.506320

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