Article
Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013
Yang Menghua, Liu Zhi, Hughes Chambers, Stern Andrew M, Wang Hui, Zhong Zengtao, Kan Biao, Fenical William, Zhu Jun
Abstract excerpt
To be successful pathogens, bacteria must often restrict the expression of virulence genes to host environments. This requires a physical or chemical marker of the host environment as well as a cognate bacterial system for sensing the presence of a host to appropriately time the activation of virulence. However, there have been remarkably few such signal-sensor pairs identified, and the molecular mechanisms for...
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