Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels

Abstract excerpt

Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. albicans metabolic model to investigate bacterial-fungal metabolic interactions in the gut as determinants of fungal abundance. We optimized the predictive capacity of our model using wild type and mutant C. albicans...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antifungal resistance and susceptibility
• Share to Gut microbiota and health
• Share to Probiotics and Fermented Foods