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A fungal metabolic regulator underlies infectious synergism during <i>Candida albicans</i> - <i>Staphylococcus</i> aureus intra-abdominal co-infection

2024-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Candida albicans and Staphylococcus aureus are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior and current work using a murine model of polymicrobial intra-abdominal infection (IAI) uncovered synergistic lethality that was driven by Candida -induced upregulation of functional S. aureus ⍺-toxin leading to polymicrobial sepsis and...

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Literature Corpus work
3d3c12b9-7790-5db4-b7fa-92ad1bb6e034
DOI
10.1101/2024.02.15.580531
Open publication

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A fungal metabolic regulator underlies infectious synergism during <i>Candida albicans</i> - <i>Staphylococcus</i> aureus intra-abdominal co-infectionDOI 10.1101/2024.02.15.580531
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