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GenoSim: A Forward-Time Genotype Simulator for Clinical and Population Genetics with Population Stratification

2026-06-25

Abstract excerpt

<h4>Motivation</h4> Next-generation sequencing studies in clinical genetics are often limited by the scarcity of human genotype data, which stems from ethical, regulatory, and economic barriers. The shortfall is sharpest in consanguineous populations, which are common in South Asia and the Middle East, where family-based designs need large pedigrees that are rarely sequenced in full. Existing simulators do not co...

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Literature Corpus work
e59db0d4-59fe-5804-ae50-0254868e6367
DOI
10.64898/2026.06.20.733503
Open publication

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GenoSim: A Forward-Time Genotype Simulator for Clinical and Population Genetics with Population StratificationDOI 10.64898/2026.06.20.733503
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