Article

Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke

2017-11-02

Abstract excerpt

<h4>Background: </h4> Monoallelic and biallelic mutations in the exonuclease TREX1 cause monogenic small vessel diseases (SVD). Given recent evidence for genetic and pathophysiological overlap between monogenic and polygenic forms of SVD, evaluation of TREX1 in small vessel stroke is warranted. <h4>Methods: </h4>: We sequenced the TREX1 gene in an exploratory cohort of patients with lacunar stroke (Edinburgh S...

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Literature Corpus work: e54f1fc7-38b9-5007-9105-4cf9bd6e42a4
DOI: 10.12688/wellcomeopenres.12631.1

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