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Article

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

Cell cycle (Georgetown, Tex.) - 15 Jun 2008

Kavanagh David, Spitzer Dirk, Kothari Parul H, Shaikh Aisha, Liszewski M Kathryn, Richards Anna, Atkinson John P

Abstract excerpt

Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE), Familial Chilblain Lupus (FCL) and Retinal Vasculopathy and Cerebral Leukodystrophy (RVCL) {a new term encompassing three independently described conditions with a common etiology--Cerebroretinal Vasculopathy (CRV), Hereditary Vascular Retinopathy (HVR) and Hereditary Endotheliopathy, Retinopathy and Nephropathy (HERNS)}--have previously been...

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Source

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Identifiers

PMID: 18583934
DOI: 10.4161/cc.7.12.6162
PMCID: PMC2825026

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.PMID 18583934Read ↗

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.Semantic proximity Read ↗

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