Article

Rare Variants in the <i>OTOG</i> Gene Are a Frequent Cause of Familial Meniere’s Disease

2019-09-21

Abstract excerpt

<h4>Objectives</h4> Meniere’s disease (MD) is a rare inner ear disorder characterized by sensorineural hearing loss, episodic vertigo and tinnitus. Familial MD has been reported in 6-9% of sporadic cases, and few genes including FAM136A, DTNA, PRKCB, SEMA3D and DPT have been involved in single families, suggesting genetic heterogeneity. In this study, the authors recruited 46 families with MD to search for rele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4a610b1-155c-53fd-a85f-393e36dc9612
DOI: 10.1101/771527

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rare Variants in the <i>OTOG</i> Gene Are a Frequent Cause of Familial Meniere’s DiseaseDOI 10.1101/771527Read

An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European descendant populationSemantic proximity Read

Excess of rare missense variants in hearing loss genes in sporadic Meniere diseaseSemantic proximity Read

Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere DiseaseSemantic proximity Read

An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European population.Semantic proximity Read

Different contribution of missense and loss-of-function variants to the genetic structure of familial and sporadic Meniere diseaseSemantic proximity Read

Replication of missense OTOG gene variants in a Brazilian cohort of Menière’s DiseaseSemantic proximity Read

Rare Missense Variants in<i>MYO7A</i>and<i>OTOP2</i>Genes in a South Korean Meniere Disease CohortSemantic proximity Read

Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease.Semantic proximity Read

Ultrarare missense and frameshift variants in the <i>TECTA</i> gene may involve tectorial membrane in familial Meniere diseaseSemantic proximity Read

Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian PopulationSemantic proximity Read

The genomic landscape of Ménière's disease: a path to endolymphatic hydropsSemantic proximity Read

Rare missense variants in MYO7A and OTOP2 genes in a South Korean Meniere's disease cohort.Semantic proximity Read