Article

An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European descendant population

2023-09-12

Abstract excerpt

<title>Abstract</title> Meniere's disease is a complex inner ear disorder with significant familial aggregation. A differential prevalence of familial MD (FMD) has been reported, being 9-10% in Europeans compared to 6% in East Asians. A broad genetic heterogeneity in FMD has been described, <italic>OTOG</italic> being the most common mutated gene, with a compound heterozygous recessive inheritance. We hypothes...

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Literature Corpus work: 8c35cbef-9f07-58da-9664-8869046f5ba4
DOI: 10.21203/rs.3.rs-3327290/v1

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