Article

Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors

2023-08-03

Abstract excerpt

<h4>SUMMARY</h4> The development of targeted therapy for patients with Multiple Myeloma (MM) is hampered by the low frequency of actionable genetic abnormalities. Gain or amplification of chr1q (Amp1q) is the most frequent arm-level copy number gain in patients with MM, and it is associated with higher risk of progression and death despite recent advances in therapeutics. Thus, developing targeted therapy for pat...

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Literature Corpus work: e4913f61-0701-5ebb-ad9d-692a0f17bbd1
DOI: 10.1101/2023.08.01.551480

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