Article

Solubility and Dissolution Study by Applying the Fusion Method of Solid Dispersion, the Hydrophobic Drugs Glimepiride Solubility is Improved

2022-09-02

Abstract excerpt

Glimepiride is a member of the third generation of sulfonylureas used to treat diabetes mellitus. Even though glimepiride has moderate water solubility, its slow rate of dissolution means that it only completely dissolves in the intestines, resulting in subtherapeutic plasma drug levels and, occasionally, an unanticipated clinical reaction. The goal of this research was to enhance the drug's solubility, rate of di...

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Identifiers and source

Literature Corpus work: e41845ae-18bd-5389-b50d-06ad6040509a
DOI: 10.21203/rs.3.rs-1985677/v1

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