Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Application of a mixed optimization strategy in the design of a pharmaceutical solid formulation at laboratory scale.

Drug development and industrial pharmacy - 1 Aug 2001

De Saavedra M S, Cuadra I S

Abstract excerpt

The objective of this work was to develop an optimization strategy for the design of pharmaceutical formulations. The mixed strategy was used to optimize a dry powder blend containing 500mg of alpha methlyl dopa to be filled into hard gelatin capsules. The experimental plan consisted of assessing blend flow and dissolution rate using formulations manufactured at small laboratory scale, selecting the optimum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Drug Design
Share to Models, Theoretical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Biology

Share to Mutation

Share to Reproducibility of Results

Share to Solubility

Share to Solutions

Source

Identifiers

PMID: 11694015
DOI: 10.1081/ddc-100107324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Application of a mixed optimization strategy in the design of a pharmaceutical solid formulation at laboratory scale.PMID 11694015Read ↗

Solubility and Dissolution Study by Applying the Fusion Method of Solid Dispersion, the Hydrophobic Drugs Glimepiride Solubility is ImprovedSemantic proximity Read ↗

Dynamic Optimization with Particle Swarms (DOPS): A meta-heuristic for parameter estimation in biochemical modelsSemantic proximity Read ↗

Optimization and Simulation of Extrusion Parameters in Polymer Compounding: A Comparative Study Using BBD and 3LFFDSemantic proximity Read ↗

Design, development and optimization of itopride hydrochloride loaded floating pellets by spheronization after compression method: In vitro and in vivo evaluationSemantic proximity Read ↗

Tuber melanosporum fermentation medium optimization by Plackett–Burman design coupled with Draper–Lin small composite design and desirability functionSemantic proximity Read ↗

Comparative study of evolutionary machine learning approaches to simulate the rheological characteristics of polybutylene succinate (PBS) utilized for fused deposition modeling (FDM)Semantic proximity Read ↗

Towards a Customized Oral Drug Therapy for Pediatric Applications: Chewable Propranolol Gel Tablets Printed by an Automated Extrusion-Based Material Deposition MethodSemantic proximity Read ↗

Automated modeling of population pharmacokinetic models using nlmixr2auto: a clinical trial and real-world data studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.