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The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

14 Aug 2019

Abstract excerpt

BACKGROUND: For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro in some human clinical trials, runs the risk of xenoimmunization and zoonotic disease transmission. To ensure that GMP standards are maintained, pooled human platelet lysate (pHPL) has been used...

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PMID: 31412930
DOI: 10.1186/s13287-019-1370-2

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