Article

Early Blood Metabolome Remodeling Reveals Metabolic Signatures of Hypoxic-Ischemic Encephalopathy

2026-04-04

Abstract excerpt

Hypoxic-ischemic encephalopathy (HIE) is a neonatal brain injury in which a definitive diagnosis within the first 6 hours of life is essential for initiating therapeutic hypothermia and improving neurological outcomes. However, early clinical evaluation and currently available biomarkers lack quantitative specificity during this narrow therapeutic window. We are providing insights into how rapid disturbances in sy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e356840f-c2f1-5a6a-b4a4-c8c2b802608b
DOI: 10.64898/2026.04.01.715878

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Blood Metabolome Remodeling Reveals Metabolic Signatures of Hypoxic-Ischemic EncephalopathyDOI 10.64898/2026.04.01.715878Read

Genetic and epigenetic contributors and mimickers of phenotypic hypoxic-ischemic encephalopathy (HIE).Semantic proximity Read

Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseasesSemantic proximity Read

Exploring the genetic landscape of neurotransmitter alterations in hypoxic-ischemic encephalopathy: A personalized medicine perspectiveSemantic proximity Read

Metabolomic Research on Newborn Infants With Intrauterine Growth RestrictionSemantic proximity Read

Applications of Metabolomics and Lipidomics in the Neonatal Intensive Care UnitSemantic proximity Read

Defining the 'Hypothermia Resistant' phenotype in neonatal HIE: persistent multi-organ dysfunction on day 3 is the hallmark of MRI injury.Semantic proximity Read

Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injurySemantic proximity Read

Single-cell Transcriptomic Profiling of Brains in Newborn Rats Following Hypoxic Ischemic EncephalopathySemantic proximity Read

Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic EncephalopathySemantic proximity Read

Genome-wide expression in neonatal encephalopathySemantic proximity Read

Maternal-offspring brain and tissue cross-talk in preeclampsia: insights from a rat modelSemantic proximity Read

Brain Biomarkers of Long-term Outcome of Neonatal Onset Urea Cycle DisorderSemantic proximity Read