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Article

Defining the 'Hypothermia Resistant' phenotype in neonatal HIE: persistent multi-organ dysfunction on day 3 is the hallmark of MRI injury.

Journal of perinatology : official journal of the California Perinatal Association - 1 Jun 2026

Sarı Emine Ergül, Salihoğlu Özgül

Abstract excerpt

OBJECTIVE: Therapeutic hypothermia (TH) reduces mortality in neonatal hypoxic-ischemic encephalopathy (HIE), yet nearly half of treated infants suffer adverse outcomes. This study aimed to define the "Hypothermia Resistance" phenotype by characterizing the 4-day trajectories of multi-organ dysfunction and identifying the physiological signals associated with severe MRI injury. STUDY DESIGN: This retrospective...

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Identifiers

PMID: 41731039
DOI: 10.1038/s41372-026-02583-3

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TH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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