Article

Low TET1 Expression Levels in COPD Are Associated with Airway and Blood Neutrophilia

2025-04-16

Abstract excerpt

Epigenetic dysregulation, particularly DNA methylation variations, is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Ten-eleven translocation (TET) proteins (TET1, TET2, and TET3) regulate DNA methylation and gene transcription. Impaired TET1 expression was previously associated with airway inflammation and asthma. Here we investigated TET gene associations with COPD severity. We f...

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Literature Corpus work: e241a8a9-244b-54f5-b5a0-8c4c16ac793b
DOI: 10.1101/2025.04.15.25325889

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