Article
Targeting KRAS mutation in gastrointestinal cancers
2023-11-13
Abstract excerpt
KRAS is the most commonly mutated gene in cancer and is associated with poor prognosis. Up to 44% of gastrointestinal cancers (GI) have KRAS mutations with the highest incidence observed in pancreatic cancer. Successfully targeting a specific mutation KRAS G12C in non-small cell lung cancer (NSCLC) has challenged the dogma that KRAS is a “non-druggable” target. With the advent of several RAS inhibitors, the opport...
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Identifiers and source
- Literature Corpus work
- e23ef33d-d2c3-58a8-bf3f-bfcbcbd9180e
- DOI
- 10.12688/f1000research.131688.1