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Article

Targeting Mutated KRAS Genes to Treat Solid Tumours.

Molecular diagnosis & therapy - 1 Jan 2022

Krishnan Tharani, Roberts-Thomson Rachel, Broadbridge Vy, Price Timothy

Abstract excerpt

Kirsten rat sarcoma (KRAS) is one of the most frequently mutated oncogenes in solid tumours. It encodes an important signalling pathway that drives cellular proliferation and growth. It is frequently mutated in aggressive advanced solid tumours, particularly colorectal, lung and pancreatic cancer. Since the first mutated KRAS was discovered in the 1980s, decades of research to develop targeted inhibitors of...

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PMID: 34914038
DOI: 10.1007/s40291-021-00564-0

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