Article
Strategies for Targeting KRAS: A Challenging Drug Target.
Current pharmaceutical design - 1 Jan 2022
Wadood Abdul, Ajmal Amar, Rehman Ashfaq Ur
Abstract excerpt
In the developed world, cancer is the most common cause of death. Among the 36 human genes of the RAS family, KRAS, NRAS, and HRAS play a prominent role in human cancer. KRAS belongs to the Ras superfamily of proteins and is a small GTPase signal transduction protein. Among the RAS isoform, KRAS is the dominant mutant that induces approximately 86% of the RAS mutations. The most frequently mutated KRAS isoform is...
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