Back to search

Article

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

2022-10-03

Abstract excerpt

LI-cadherin is a member of the cadherin superfamily. LI-cadherin mediates Ca 2+ -dependent cell-cell adhesion by forming a homodimer. A previous study reported two single nucleotide polymorphisms (SNPs) in the LI-cadherin-coding gene ( CDH17 ). These SNPs correspond to the amino acid changes of Lys115 to Glu and Glu739 to Ala. Patients with colorectal cancer carrying these SNPs are reported to have a higher risk...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e1c62c67-371b-5e7d-99e6-94286bf6d437
DOI
10.1101/2022.10.02.510515
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin geneDOI 10.1101/2022.10.02.510515
Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.Semantic proximity
CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the diseaseSemantic proximity
Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene.Semantic proximity
MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer.Semantic proximity
Association of CD44 gene rs187115 polymorphism with colorectal cancer risk and prognosis in Chinese Han population: a case-control study.Semantic proximity
Nine novel single-nucleotide polymorphisms in the integrin beta4 (ITGB4) gene in the Japanese population.Semantic proximity
A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population.Semantic proximity
Exploring the mechanism of a regulatory SNP of KLK3 by molecular dynamics simulation.Semantic proximity
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Semantic proximity
Select a neighboring publication to make it the new centre.