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Article

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.

Scientific reports - 20 Apr 2023

Yui Anna, Kuroda Daisuke, Maruno Takahiro, Nakakido Makoto, Nagatoishi Satoru, Uchiyama Susumu, Tsumoto Kouhei

Abstract excerpt

LI-cadherin is a member of the cadherin superfamily. LI-cadherin mediates Ca2+-dependent cell-cell adhesion through homodimerization. A previous study reported two single nucleotide polymorphisms (SNPs) in the LI-cadherin-coding gene (CDH17). These SNPs correspond to the amino acid changes of Lys115 to Glu and Glu739 to Ala. Patients with colorectal cancer carrying these SNPs are reported to have a higher risk of...

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Identifiers

PMID: 37081068
DOI: 10.1038/s41598-023-32444-4
PMCID: PMC10117238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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