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Treating the untreatable: Reversing β-lactam resistance in MRSA by membrane-domain-dissolving antibiotics

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Antimicrobial resistance is one of the most serious threats to global health with methicillin-resistant Staphylococcus aureus (MRSA) being the leading Gram-positive pathogen. Recently we discovered a new antimicrobial target for small antibiotics — dissolution of functional domains in the bacterial membrane without pore formation. Here we apply this mechanism to reverse β-lactam resistance in M...

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Literature Corpus work
e18d202b-ffca-5b20-aacf-73a702823782
DOI
10.1101/2025.10.27.684379
Open publication

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Treating the untreatable: Reversing β-lactam resistance in MRSA by membrane-domain-dissolving antibioticsDOI 10.1101/2025.10.27.684379
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