Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

9 Apr 2024

Abstract excerpt

During aging, skin homeostasis is essential for maintaining appearance, as well as biological defense of the human body. In this study, we identified thrombospondin-1 (THBS1) and fibromodulin (FMOD) as positive and negative regulators, respectively, of the TGF-β1-SMAD4 axis in human skin aging, based on in vitro and in vivo omics analyses and mathematical modeling. Using transcriptomic and epigenetic analyses of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Circadian rhythm and melatonin
Share to Skin Protection and Aging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38706856
DOI: 10.1016/j.isci.2024.109708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin agingPMID 38706856Read ↗

Positive and negative feedback regulation of the TGF-β1–SMAD4 axis explains two equilibrium states in human skin agingSemantic proximity Read ↗

The effect of aging in primary human dermal fibroblastsSemantic proximity Read ↗

Identification of biological processes and potential inhibitors for aging skinSemantic proximity Read ↗

Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosisSemantic proximity Read ↗

Alteration of the TGF-β/SMAD pathway in intrinsically and UV-induced skin agingSemantic proximity Read ↗

Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.Semantic proximity Read ↗

Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1.Semantic proximity Read ↗

TGF-β in aging and diseaseSemantic proximity Read ↗

Exploring the impact of TGF-β family gene mutations and expression on skin wound healing and tissue repair.Semantic proximity Read ↗

Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue agingSemantic proximity Read ↗

Celluar Senescence-Related Gene Signatures as Predictive Markers and Regulatory Mechanisms in Diabetic Foot UlcersSemantic proximity Read ↗

Oxidative Stress and Human Skin Connective Tissue AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.