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15-keto-prostaglandin E <sub>2</sub> activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote <i>Cryptococcus neoformans</i> growth during infection

2017-03-02

Abstract excerpt

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. However, the specific mechanisms by which C. neoformans manipulates host immunity to promote its growth during infection remain ill-defined. Here we demonstrate that eicosanoid lipid mediators man...

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Literature Corpus work
e08f8557-fc0a-5b1b-8794-c307881829da
DOI
10.1101/113167
Open publication

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15-keto-prostaglandin E <sub>2</sub> activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote <i>Cryptococcus neoformans</i> growth during infectionDOI 10.1101/113167
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