Article

Odd-chain dicarboxylic acid feeding recapitulates the biochemical phenotype of glutaric aciduria type 1 in mice

2025-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of glutaric aciduria, 3-hydroxyglutaric aciduria, and increased plasma glutarylcarnitine. These glutaryl-CoA-derived metabolites are thought to originate solely in the mitochondri...

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Literature Corpus work: e07acd0b-63c1-5324-a0e3-518fe5905d84
DOI: 10.1101/2025.02.13.637994

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