Lentiviral vectors transduce lung stem cells without disrupting plasticity

Abstract excerpt

Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vector containing a GFP or cystic fibrosis transmembrane conductance regulator ( CFTR ) transgene to transduce primary airway basal cells from human cystic fibrosis (CF)...

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