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Article

Effect of NOTCH3 EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes.

Stroke - 1 Oct 2022

Hack Remco J, Cerfontaine Minne N, Gravesteijn Gido, Tap Stephan, Hafkemeijer Anne, van der Grond Jeroen, Witjes-Ané Marie-Noëlle, Baas Frank, Rutten Julie W, Lesnik Oberstein Saskia A J

Abstract excerpt

BACKGROUND: A retrospective study has shown that EGFr (epidermal growth factor-like repeat) group in the NOTCH3 gene is an important cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) disease modifier of age at first stroke and white matter hyperintensity (WMH) volume. No study has yet assessed the effect of other known CADASIL modifiers, that is, cardiovascular...

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Identifiers

PMID: 35862191
DOI: 10.1161/STROKEAHA.122.039325
PMCID: PMC9508953

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Effect of NOTCH3 EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes.PMID 35862191Read ↗

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