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Article

Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.

Journal of the American Heart Association - 21 Nov 2023

Cheng Yu-Wen, Liao Yi-Chu, Chen Chih-Hao, Chung Chih-Ping, Fann Cathy S J, Chang Chien-Ching, Lee Yi-Chung, Tang Sung-Chun

Abstract excerpt

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small-vessel disease. Phenotype variability in CADASIL suggests the possible role of genetic modifiers. We aimed to investigate the contributions of the APOE genotype and Neurogenic locus notch homolog protein 3 (NOTCH3) variant position to cognitive impairment...

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Source

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Identifiers

PMID: 37982214
DOI: 10.1161/JAHA.123.032689
PMCID: PMC10727295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.PMID 37982214Read ↗

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