Article

Deep learning inference of universal dormancy pseudotime reveals the cellular targets of anti-cancer therapies

2025-12-16

Abstract excerpt

Controlled exit from and re-entry into the cell cycle is essential for multi-cellular life, while aberrant quiescent and senescent cell states have been implicated in age-related diseases and cancer treatment evasion. Recent molecular and imaging studies suggest non-cycling cellular states exist along a continuum of deepening dormancy, whereby the probability of cell cycle re-entry decreases with distance from the...

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Literature Corpus work: dfcfba1d-d2bb-5ff4-b85c-d4bc945ce1e1
DOI: 10.64898/2025.12.14.692655

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