Article

Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell Preparations

2022-02-10

Abstract excerpt

Mesenchymal stromal cell (MSC) heterogeneity clouds biological understanding and hampers their clinical development. In MSC cultures most commonly used in research and therapy, we have identified an MSC subtype characterised by CD317 expression (CD317 pos (29.77±3.00% of the total MSC population), comprising CD317 dim (28.10±4.60%) and CD317 bright (1.67±0.58%) MSCs) and a constitutive interferon signature link...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df5efadf-47f8-5ac9-8c3f-664ec20965c6
DOI: 10.1101/2022.02.10.479972

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell PreparationsDOI 10.1101/2022.02.10.479972Read

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative MedicineSemantic proximity Read

Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes.Semantic proximity Read

Mesenchymal stem cells—the master immunomodulatorsSemantic proximity Read

Mesenchymal Stem/Stromal Cells: A Review for Its Use After Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read

Revisiting the Mesenchymal “Stem vs. Stromal” Cell Dichotomy and Its Implications for Development of Improved Potency MetricsSemantic proximity Read

Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage PolarizationSemantic proximity Read

Infrapatellar Fat Pad-derived Mesenchymal Stem Cell-based Spheroids Enhance Their Therapeutic Efficacy to Reverse Synovitis and Fat Pad FibrosisSemantic proximity Read

Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug DeliverySemantic proximity Read

The immunomodulatory function of mesenchymal stem cells: mode of action and pathwaysSemantic proximity Read

Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype.Semantic proximity Read

Immunoregulatory function of mesenchymal stem cellsSemantic proximity Read

Mesenchymal Stem Cell Population Derived from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and Therapeutic PropertiesSemantic proximity Read